AustralieFrV1, Main, Exploration, bibRecord, 006D19

Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: A Meta-Analysis of Over 6,000 Children

Identifieur interne : 006D19 ( Main/Exploration ); précédent : 006D18; suivant : 006D20

Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: A Meta-Analysis of Over 6,000 Children

Auteurs : Adam Barker [Royaume-Uni] ; Stephen J. Sharp [Royaume-Uni] ; Nicholas J. Timpson [Royaume-Uni] ; Nabila Bouatia-Naji [France] ; Nicole M. Warrington [Australie] ; Stavroula Kanoni [Grèce, Royaume-Uni] ; Lawrence J. Beilin [Australie] ; Soren Brage [Royaume-Uni] ; Panos Deloukas [Royaume-Uni] ; David M. Evans [Royaume-Uni] ; Anders Grontved [Danemark] ; Neelam Hassanali [Royaume-Uni] ; Deborah A. Lawlor [Royaume-Uni] ; Cecile Lecoeur [France] ; Ruth J. F. Loos [Royaume-Uni] ; Stephen J. Lye [Canada] ; Mark I. Mccarthy [Royaume-Uni] ; Trevor A. Mori [Australie] ; Ndeye Coumba Ndiaye [France] ; John P. Newnham [Australie] ; Ioanna Ntalla [Grèce] ; Craig E. Pennell [Australie] ; Beate St Pourcain [Royaume-Uni] ; Inga Prokopenko [Royaume-Uni] ; Susan M. Ring [Royaume-Uni] ; Naveed Sattar [Royaume-Uni] ; Sophie Visvikis-Siest [France] ; George V. Dedoussis [Grèce] ; Lyle J. Palmer [Canada] ; Philippe Froguel [France, Royaume-Uni] ; George Davey Smith [Royaume-Uni] ; Ulf Ekelund [Royaume-Uni, Suède] ; Nicholas J. Wareham [Royaume-Uni] ; Claudia Langenberg [Royaume-Uni]

Source :

Diabetes : (New York, NY) [ 0012-1797 ] ; 2011.

RBID : Pascal:11-0284509

Descripteurs français

Pascal (Inist)
- Association, Génétique, Glucose, Diabète, Enfant.
Wicri :
- topic : Association, Génétique, Glucose, Diabète, Enfant.

English descriptors

KwdEn :
- Association, Child, Diabetes mellitus, Genetics, Glucose.

Abstract

OBJECTIVE-To investigate whether associations of common genetic variants recently identified for fasting glucose or insulin levels in nondiabetic adults are detectable in healthy children and adolescents. RESEARCH DESIGN AND METHODS-A total of 16 single nucleotide polymorphisms (SNPs) associated with fasting glucose were genotyped in six studies of children and adolescents of European origin, including over 6,000 boys and girls aged 9-16 years. We performed meta-analyses to test associations of individual SNPs and a weighted risk score of the 16 loci with fasting glucose. RESULTS-Nine loci were associated with glucose levels in healthy children and adolescents, with four of these associations reported in previous studies and five reported here for the first time (GLIS3, PROX1, SLC2A2, ADCY5, and CRY2). Effect sizes were similar to those in adults, suggesting age-independent effects of these fasting glucose loci. Children and adolescents carrying glucose-raising alleles of G6PC2, MTNR1B, GCK, and GLIS3 also showed reduced β-cell function, as indicated by homeostasis model assessment of β-cell function. Analysis using a weighted risk score showed an increase [β (95% CI)] in fasting glucose level of 0.026 mmol/L (0.021-0.031) for each unit increase in the score. CONCLUSIONS-Novel fasting glucose loci identified in genomewide association studies of adults are associated with altered fasting glucose levels in healthy children and adolescents with effect sizes comparable to adults. In nondiabetic adults, fasting glucose changes little over time, and our results suggest that age-independent effects of fasting glucose loci contribute to long-term interindividual differences in glucose levels from childhood onwards.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114379

Affiliations:

Le document en format XML

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<affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1>
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<s3>GBR</s3>
<sZ>12 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>17 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>The Avon Longitudinal Study of Parents and Children, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<affiliation wicri:level="4"><inist:fA14 i1="16"><s1>British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow</s1>
<s2>Glasgow</s2>
<s3>GBR</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Visvikis Siest, Sophie" sort="Visvikis Siest, Sophie" uniqKey="Visvikis Siest S" first="Sophie" last="Visvikis-Siest">Sophie Visvikis-Siest</name>
<affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Cardiovascular Genetics" Research Unit, Universite Henri Poincare</s1>
<s2>Nancy</s2>
<s3>FRA</s3>
<sZ>19 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Grand Est</region>
<region type="old region">Lorraine (région)</region>
<settlement type="city">Nancy</settlement>
<settlement type="city">Nancy</settlement>
</placeName>
<orgName type="university">Université Henri Poincaré</orgName>
</affiliation>
</author>
<author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Nutrition-Dietetics, Harokopio University</s1>
<s2>Athens</s2>
<s3>GRC</s3>
<sZ>6 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Grèce</country>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
<settlement type="city">Athènes</settlement>
</placeName>
<orgName type="university">Université Harokopio</orgName>
</affiliation>
</author>
<author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name>
<affiliation wicri:level="4"><inist:fA14 i1="17"><s1>Ontario Institute for Cancer Research, University of Toronto</s1>
<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>CNRS UMR 8199, Institut Pasteur de Lille</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Lille Nord de France University</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MRC Centre for Causal Analyses in Translational Epidemiology (MRC CAiTE), University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
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<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ekelund, Ulf" sort="Ekelund, Ulf" uniqKey="Ekelund U" first="Ulf" last="Ekelund">Ulf Ekelund</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council Epidemiology Unit, Addenbrooke's Hospital, Institute of Metabolic Science</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
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<sZ>15 aut.</sZ>
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</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>School of Health and Medical Sciences, Orebro University</s1>
<s2>Orebro</s2>
<s3>SWE</s3>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Orebro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council Epidemiology Unit, Addenbrooke's Hospital, Institute of Metabolic Science</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<sZ>15 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council Epidemiology Unit, Addenbrooke's Hospital, Institute of Metabolic Science</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">11-0284509</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: A Meta-Analysis of Over 6,000 Children</title>
<author><name sortKey="Barker, Adam" sort="Barker, Adam" uniqKey="Barker A" first="Adam" last="Barker">Adam Barker</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council Epidemiology Unit, Addenbrooke's Hospital, Institute of Metabolic Science</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sharp, Stephen J" sort="Sharp, Stephen J" uniqKey="Sharp S" first="Stephen J." last="Sharp">Stephen J. Sharp</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council Epidemiology Unit, Addenbrooke's Hospital, Institute of Metabolic Science</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Timpson, Nicholas J" sort="Timpson, Nicholas J" uniqKey="Timpson N" first="Nicholas J." last="Timpson">Nicholas J. Timpson</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MRC Centre for Causal Analyses in Translational Epidemiology (MRC CAiTE), University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>CNRS UMR 8199, Institut Pasteur de Lille</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Lille Nord de France University</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Warrington, Nicole M" sort="Warrington, Nicole M" uniqKey="Warrington N" first="Nicole M." last="Warrington">Nicole M. Warrington</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>School of Women's and Infants' Health, The University of Western Australia</s1>
<s2>Perth</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kanoni, Stavroula" sort="Kanoni, Stavroula" uniqKey="Kanoni S" first="Stavroula" last="Kanoni">Stavroula Kanoni</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Nutrition-Dietetics, Harokopio University</s1>
<s2>Athens</s2>
<s3>GRC</s3>
<sZ>6 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Grèce</country>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
<settlement type="city">Athènes</settlement>
</placeName>
<orgName type="university">Université Harokopio</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</s1>
<s2>Hinxton</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Hinxton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Beilin, Lawrence J" sort="Beilin, Lawrence J" uniqKey="Beilin L" first="Lawrence J." last="Beilin">Lawrence J. Beilin</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>School of Medicine and Pharmacology, The University of Western Australia</s1>
<s2>Perth</s2>
<s3>AUS</s3>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brage, Soren" sort="Brage, Soren" uniqKey="Brage S" first="Soren" last="Brage">Soren Brage</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council Epidemiology Unit, Addenbrooke's Hospital, Institute of Metabolic Science</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deloukas, Panos" sort="Deloukas, Panos" uniqKey="Deloukas P" first="Panos" last="Deloukas">Panos Deloukas</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus</s1>
<s2>Hinxton</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Hinxton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Evans, David M" sort="Evans, David M" uniqKey="Evans D" first="David M." last="Evans">David M. Evans</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MRC Centre for Causal Analyses in Translational Epidemiology (MRC CAiTE), University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Grontved, Anders" sort="Grontved, Anders" uniqKey="Grontved A" first="Anders" last="Grontved">Anders Grontved</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>University of Southern Denmark</s1>
<s2>Odense</s2>
<s3>DNK</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Danemark</country>
<wicri:noRegion>University of Southern Denmark</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hassanali, Neelam" sort="Hassanali, Neelam" uniqKey="Hassanali N" first="Neelam" last="Hassanali">Neelam Hassanali</name>
<affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>12 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Lawlor, Deborah A" sort="Lawlor, Deborah A" uniqKey="Lawlor D" first="Deborah A." last="Lawlor">Deborah A. Lawlor</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MRC Centre for Causal Analyses in Translational Epidemiology (MRC CAiTE), University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lecoeur, Cecile" sort="Lecoeur, Cecile" uniqKey="Lecoeur C" first="Cecile" last="Lecoeur">Cecile Lecoeur</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>CNRS UMR 8199, Institut Pasteur de Lille</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Lille Nord de France University</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Loos, Ruth J F" sort="Loos, Ruth J F" uniqKey="Loos R" first="Ruth J. F." last="Loos">Ruth J. F. Loos</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council Epidemiology Unit, Addenbrooke's Hospital, Institute of Metabolic Science</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lye, Stephen J" sort="Lye, Stephen J" uniqKey="Lye S" first="Stephen J." last="Lye">Stephen J. Lye</name>
<affiliation wicri:level="4"><inist:fA14 i1="12"><s1>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto</s1>
<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Mccarthy, Mark I" sort="Mccarthy, Mark I" uniqKey="Mccarthy M" first="Mark I." last="Mccarthy">Mark I. Mccarthy</name>
<affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>12 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>17 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Mori, Trevor A" sort="Mori, Trevor A" uniqKey="Mori T" first="Trevor A." last="Mori">Trevor A. Mori</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>School of Medicine and Pharmacology, The University of Western Australia</s1>
<s2>Perth</s2>
<s3>AUS</s3>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Coumba Ndiaye, Ndeye" sort="Coumba Ndiaye, Ndeye" uniqKey="Coumba Ndiaye N" first="Ndeye" last="Coumba Ndiaye">Ndeye Coumba Ndiaye</name>
<affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Cardiovascular Genetics" Research Unit, Universite Henri Poincare</s1>
<s2>Nancy</s2>
<s3>FRA</s3>
<sZ>19 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Grand Est</region>
<region type="old region">Lorraine (région)</region>
<settlement type="city">Nancy</settlement>
<settlement type="city">Nancy</settlement>
</placeName>
<orgName type="university">Université Henri Poincaré</orgName>
</affiliation>
</author>
<author><name sortKey="Newnham, John P" sort="Newnham, John P" uniqKey="Newnham J" first="John P." last="Newnham">John P. Newnham</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>School of Women's and Infants' Health, The University of Western Australia</s1>
<s2>Perth</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ntalla, Ioanna" sort="Ntalla, Ioanna" uniqKey="Ntalla I" first="Ioanna" last="Ntalla">Ioanna Ntalla</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Nutrition-Dietetics, Harokopio University</s1>
<s2>Athens</s2>
<s3>GRC</s3>
<sZ>6 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Grèce</country>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
<settlement type="city">Athènes</settlement>
</placeName>
<orgName type="university">Université Harokopio</orgName>
</affiliation>
</author>
<author><name sortKey="Pennell, Craig E" sort="Pennell, Craig E" uniqKey="Pennell C" first="Craig E." last="Pennell">Craig E. Pennell</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>School of Women's and Infants' Health, The University of Western Australia</s1>
<s2>Perth</s2>
<s3>AUS</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pourcain, Beate St" sort="Pourcain, Beate St" uniqKey="Pourcain B" first="Beate St" last="Pourcain">Beate St Pourcain</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>The Avon Longitudinal Study of Parents and Children, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<affiliation wicri:level="4"><inist:fA14 i1="11"><s1>Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>12 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
<affiliation wicri:level="4"><inist:fA14 i1="13"><s1>Wellcome Trust Centre for Human Genetics, University of Oxford</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>17 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Ring, Susan M" sort="Ring, Susan M" uniqKey="Ring S" first="Susan M." last="Ring">Susan M. Ring</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>The Avon Longitudinal Study of Parents and Children, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<affiliation wicri:level="4"><inist:fA14 i1="16"><s1>British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow</s1>
<s2>Glasgow</s2>
<s3>GBR</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author><name sortKey="Visvikis Siest, Sophie" sort="Visvikis Siest, Sophie" uniqKey="Visvikis Siest S" first="Sophie" last="Visvikis-Siest">Sophie Visvikis-Siest</name>
<affiliation wicri:level="4"><inist:fA14 i1="14"><s1>Cardiovascular Genetics" Research Unit, Universite Henri Poincare</s1>
<s2>Nancy</s2>
<s3>FRA</s3>
<sZ>19 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Grand Est</region>
<region type="old region">Lorraine (région)</region>
<settlement type="city">Nancy</settlement>
<settlement type="city">Nancy</settlement>
</placeName>
<orgName type="university">Université Henri Poincaré</orgName>
</affiliation>
</author>
<author><name sortKey="Dedoussis, George V" sort="Dedoussis, George V" uniqKey="Dedoussis G" first="George V." last="Dedoussis">George V. Dedoussis</name>
<affiliation wicri:level="4"><inist:fA14 i1="07"><s1>Department of Nutrition-Dietetics, Harokopio University</s1>
<s2>Athens</s2>
<s3>GRC</s3>
<sZ>6 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Grèce</country>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
<settlement type="city">Athènes</settlement>
</placeName>
<orgName type="university">Université Harokopio</orgName>
</affiliation>
</author>
<author><name sortKey="Palmer, Lyle J" sort="Palmer, Lyle J" uniqKey="Palmer L" first="Lyle J." last="Palmer">Lyle J. Palmer</name>
<affiliation wicri:level="4"><inist:fA14 i1="17"><s1>Ontario Institute for Cancer Research, University of Toronto</s1>
<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>CNRS UMR 8199, Institut Pasteur de Lille</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Lille Nord de France University</s1>
<s2>Lille</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey Smith">George Davey Smith</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>MRC Centre for Causal Analyses in Translational Epidemiology (MRC CAiTE), University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>School of Social and Community Medicine, University of Bristol</s1>
<s2>Bristol</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Bristol</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ekelund, Ulf" sort="Ekelund, Ulf" uniqKey="Ekelund U" first="Ulf" last="Ekelund">Ulf Ekelund</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council Epidemiology Unit, Addenbrooke's Hospital, Institute of Metabolic Science</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>School of Health and Medical Sciences, Orebro University</s1>
<s2>Orebro</s2>
<s3>SWE</s3>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Suède</country>
<wicri:noRegion>Orebro</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J." last="Wareham">Nicholas J. Wareham</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council Epidemiology Unit, Addenbrooke's Hospital, Institute of Metabolic Science</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Medical Research Council Epidemiology Unit, Addenbrooke's Hospital, Institute of Metabolic Science</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Diabetes : (New York, NY)</title>
<title level="j" type="abbreviated">Diabetes : (N.Y. NY)</title>
<idno type="ISSN">0012-1797</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Diabetes : (New York, NY)</title>
<title level="j" type="abbreviated">Diabetes : (N.Y. NY)</title>
<idno type="ISSN">0012-1797</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term>
<term>Child</term>
<term>Diabetes mellitus</term>
<term>Genetics</term>
<term>Glucose</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Association</term>
<term>Génétique</term>
<term>Glucose</term>
<term>Diabète</term>
<term>Enfant</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term>
<term>Génétique</term>
<term>Glucose</term>
<term>Diabète</term>
<term>Enfant</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">OBJECTIVE-To investigate whether associations of common genetic variants recently identified for fasting glucose or insulin levels in nondiabetic adults are detectable in healthy children and adolescents. RESEARCH DESIGN AND METHODS-A total of 16 single nucleotide polymorphisms (SNPs) associated with fasting glucose were genotyped in six studies of children and adolescents of European origin, including over 6,000 boys and girls aged 9-16 years. We performed meta-analyses to test associations of individual SNPs and a weighted risk score of the 16 loci with fasting glucose. RESULTS-Nine loci were associated with glucose levels in healthy children and adolescents, with four of these associations reported in previous studies and five reported here for the first time (GLIS3, PROX1, SLC2A2, ADCY5, and CRY2). Effect sizes were similar to those in adults, suggesting age-independent effects of these fasting glucose loci. Children and adolescents carrying glucose-raising alleles of G6PC2, MTNR1B, GCK, and GLIS3 also showed reduced β-cell function, as indicated by homeostasis model assessment of β-cell function. Analysis using a weighted risk score showed an increase [β (95% CI)] in fasting glucose level of 0.026 mmol/L (0.021-0.031) for each unit increase in the score. CONCLUSIONS-Novel fasting glucose loci identified in genomewide association studies of adults are associated with altered fasting glucose levels in healthy children and adolescents with effect sizes comparable to adults. In nondiabetic adults, fasting glucose changes little over time, and our results suggest that age-independent effects of fasting glucose loci contribute to long-term interindividual differences in glucose levels from childhood onwards.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>Danemark</li>
<li>France</li>
<li>Grèce</li>
<li>Royaume-Uni</li>
<li>Suède</li>
</country>
<region><li>Angleterre</li>
<li>Attique (région)</li>
<li>Grand Est</li>
<li>Grand Londres</li>
<li>Hauts-de-France</li>
<li>Lorraine (région)</li>
<li>Nord-Pas-de-Calais</li>
<li>Ontario</li>
<li>Oxfordshire</li>
<li>Écosse</li>
</region>
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   |texte=   Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: A Meta-Analysis of Over 6,000 Children
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Serveur d'exploration sur les relations entre la France et l'Australie

Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: A Meta-Analysis of Over 6,000 Children

Association of Genetic Loci With Glucose Levels in Childhood and Adolescence: A Meta-Analysis of Over 6,000 Children

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	Serveur d'exploration sur les relations entre la France et l'Australie
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